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Last Updated: December 8, 2021

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Patent: 8,993,721

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Summary for Patent: 8,993,721
Title:Peptides for targeting apoptotic cells and uses thereof
Abstract: Described herein is an isolated polypeptide which is capable of specifically targeting apoptotic cells undergoing apoptosis and consists of the sequence (I): Cys-X.sub.1-Val-Ala-Pro-X.sub.2 (I), wherein X.sub.1 is an amino acid with polar uncharged side chain and X.sub.2 is an amino acid with positive charged side chain. The isolated polypeptide of the present invention may be useful for detecting apoptotic cells, as well as detecting and imaging apoptotic cells in tumor tissue, apoptotic myocardial cells in myocardial infarction tissue, apoptotic nerve cells in stroke tissue, and arteriosclerosis site; the polypeptide is useful for targeted drug delivery thereto.
Inventor(s): Lee; Byung Heon (Daegu, KR), Kim; In San (Daegu, KR)
Assignee: Kyungpook National University Industry-Academic Cooperation Foundation (N/A)
Application Number:13/467,689
Patent Claims:see list of patent claims

Details for Patent 8,993,721

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Microbix Biosystems Inc. KINLYTIC urokinase For Injection 021846 1978-01-16 ⤷  Free Forever Trial 2028-05-14
Genentech, Inc. ACTIVASE alteplase For Injection 103172 1987-11-13 ⤷  Free Forever Trial 2028-05-14
Genentech, Inc. CATHFLO ACTIVASE alteplase For Injection 103172 2001-09-04 ⤷  Free Forever Trial 2028-05-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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