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Generated: July 23, 2019

DrugPatentWatch Database Preview

Patent: 8,980,569

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Summary for Patent: 8,980,569
Title:Chronic lymphocytic leukemia prognosis and treatment
Abstract: Provided herein are methods for identifying a subject afflicted with chronic lymphocytic leukemia who is responsive to treatment with a chemotherapeutic agent by detecting the presence or absence of at least one APOE4 allele in the subject, the presence of an APOE4 allele identifying the subject as responsive to the treatment. Also provided are methods of treating a subject afflicted with chronic lymphocytic leukemia, including administering an estrogenic agent, an androgen withdrawal agent, an apoE4 peptide or mimetic thereof, and/or a chemotherapeutic agent in an amount effective to treat said chronic lymphocytic leukemia. Methods of determining a prognosis for a patient diagnosed with chronic lymphocytic leukemia are also provided. In addition, methods for stratifying a subject into a subgroup of a clinical trial and methods for identifying a patient in a clinical trial of a treatment for chronic lymphocytic leukemia are herein provided.
Inventor(s): Weinberg; J. Brice (Durham, NC), Strittmatter; Warren J. (Hillsborough, NC)
Assignee: Duke University (Durham, NC)
Application Number:13/010,005
Patent Claims:see list of patent claims

Details for Patent 8,980,569

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Glaxo Grp Ltd ARZERRA ofatumumab INJECTABLE; INJECTION 125326 001 2009-10-26 ➤ Sign Up Duke University (Durham, NC) ➤ Sign Up RX search
Genzyme LEMTRADA alemtuzumab INJECTABLE;INJECTION 103948 003 2001-05-07 ➤ Sign Up Duke University (Durham, NC) ➤ Sign Up RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 002 2001-05-07 ➤ Sign Up Duke University (Durham, NC) ➤ Sign Up RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07 ➤ Sign Up Duke University (Durham, NC) ➤ Sign Up RX Orphan search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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Serving hundreds of leading biopharmaceutical companies globally:

Moodys
Mallinckrodt
Johnson and Johnson
Queensland Health
US Army
Chubb

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