Patent: 8,946,175
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Summary for Patent: 8,946,175
Title: | Stabilized immunomodulatory oligonucleotides |
Abstract: | The invention provides immunostimulatory oligonucleotides having at least one CpG dinucleotide and a secondary structure at the 5\'- or 3\'-end. These oligonucleotides have either reduced or improved immunostimulatory properties. The invention establishes that 5\'-terminal secondary structures affect immunostimulatory activity significantly more than those at the 3\'-end. The invention also provides methods for increasing or decreasing the immunostimulatory activity of a CpG-containing nucleic acid. |
Inventor(s): | Kandimalla; Ekambar R. (Hopkinton, MA), Bhagat; Lakshmi (Framingham, MA), Pandey; Rajendra K. (Framingham, MA), Yu; Dong (Westboro, MA), Agrawal; Sudhir (Shrewsbury, MA) |
Assignee: | Idera Pharmaceuticals, Inc. (Cambridge, MA) |
Application Number: | 13/210,903 |
Patent Claims: | see list of patent claims |
Details for Patent 8,946,175
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Teknika Llc | N/A | bcg vaccine | For Injection | 103050 | 06/21/1989 | ⤷ Try a Trial | 2023-06-11 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |