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Generated: September 19, 2019

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Patent: 8,945,918

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Summary for Patent: 8,945,918
Title:Expression in insect cells of genes with overlapping open reading frames, methods and compositions therefor
Abstract: The present teachings disclose nucleic acid cassettes for expressing in an insect cell a plurality of polypeptides encoded by a gene comprising overlapping open reading frames (ORFs). A cassette comprises, in 5\' to 3\' order, a) a first insect cell-operable promoter, b) a 5\' portion of a gene comprising a first ORF of the gene, c) an intron comprising a second insect cell-operable promoter, and d) a 3\' portion of the gene comprising at least one additional ORF. Vectors and insect cells comprising the cassettes are also disclosed, as well as methods for production of recombinant adeno-associated virus in insect cells using the cassettes.
Inventor(s): Chen; Haifeng (Castro Valley, CA)
Assignee: Virovek, Inc. (Hayward, CA)
Application Number:12/297,958
Patent Claims:see list of patent claims

Details for Patent 8,945,918

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up Virovek, Inc. (Hayward, CA) 2026-08-24 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up Virovek, Inc. (Hayward, CA) 2026-08-24 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up Virovek, Inc. (Hayward, CA) 2026-08-24 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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