Low-permeability, laser-activated drug delivery device
An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
Coppeta; Jonathan Robert (Windham, NH), Horne; Kenneth N. (San Francisco, CA), Santini, Jr.; John T. (North Chelmsford, MA), Scholl; John A. (San Ramon, CA), Spooner; Gregory J. R. (San Francisco, CA), Stevenson; Cynthia L. (Mountain View, CA), Shams; Naveed (Danville, CA), Poutiatine; Andrew (Mill Valley, CA)
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