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Last Updated: September 21, 2020

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Patent: 8,906,847

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Summary for Patent: 8,906,847
Title:Prodrug comprising a drug linker conjugate
Abstract: The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof comprising a drug linker conjugate D-L, wherein -D is an amine containing biologically active moiety; and -L is a non-biologically active linker moiety -L.sup.1 represented by formula (I), wherein the dashed line indicates the attachment to the amine of the biologically active moiety and wherein R.sup.1, R.sup.1a, R.sup.2, R.sup.2a, R.sup.3, R.sup.3a, X, X.sup.1, X.sup.2, X.sup.3 have the meaning as indicated in the description and the claims and wherein L.sup.1 is substituted with one to four groups L.sup.2-Z and optionally further substituted, provided that the hydrogen marked with the asterisk in formula (I) is not replaced by a substituent; wherein L.sup.2 is a single chemical bond or a spacer; and Z is a carrier group. The invention also relates to A-L, wherein A is a leaving group, pharmaceutical composition comprising said prodrugs and their use as medicaments. ##STR00001##
Inventor(s): Cleemann; Felix (Heidelberg, DE), Hersel; Ulrich (Heidelberg, DE), Kaden; Silvia (Heidelberg, DE), Rau; Harald (Heidelberg, DE), Wegge; Thomas (Heidelberg, DE)
Assignee: Ascendis Pharma A/S (Hellerup, DK)
Application Number:12/865,693
Patent Claims:see list of patent claims

Details for Patent 8,906,847

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 004 1975-06-26   Start Trial Ascendis Pharma A/S (Hellerup, DK) 2028-02-01 RX search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 006 1975-06-26   Start Trial Ascendis Pharma A/S (Hellerup, DK) 2028-02-01 RX search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 007 1975-06-26   Start Trial Ascendis Pharma A/S (Hellerup, DK) 2028-02-01 RX search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 009 1975-06-26   Start Trial Ascendis Pharma A/S (Hellerup, DK) 2028-02-01 RX search
Ferring CHORIONIC GONADOTROPIN gonadotropin, chorionic INJECTABLE;INJECTION 017016 010 1975-06-26   Start Trial Ascendis Pharma A/S (Hellerup, DK) 2028-02-01 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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