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Last Updated: September 28, 2020

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Patent: 8,865,220

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Summary for Patent: 8,865,220
Title:Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres
Abstract: The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 .mu.m, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly(lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.
Inventor(s): Ho; Mei-Ling (Kaohsiung, TW), Wang; Gwo-Jaw (Taipei, TW), Chang; Je-Ken (Kaohsiung, TW), Fu; Yin-Chih (Kaohsiung, TW), Tzeng; Cherng-Chyi (Kaohsiung, TW), Rajalakshmanan; Eswaramoorthy (Kaohsiung, TW)
Assignee: Kaohsiung Medical University (Kaohsiung, TW)
Application Number:12/814,955
Patent Claims:see list of patent claims

Details for Patent 8,865,220

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Kaohsiung Medical University (Kaohsiung, TW) 2039-03-29 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Kaohsiung Medical University (Kaohsiung, TW) 2039-03-29 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Kaohsiung Medical University (Kaohsiung, TW) 2039-03-29 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Kaohsiung Medical University (Kaohsiung, TW) 2039-03-29 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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