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Generated: September 17, 2019

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Patent: 8,865,176

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Summary for Patent: 8,865,176
Title:Methods and compositions for generating bioactive assemblies of increased complexity and uses
Abstract: The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which takes advantage of the specific binding interaction between dimerization and docking domains (DDD) and anchoring domains (AD) to form the assembly. In various embodiments, one or more effectors may be attached to a DDD or AD sequence. Complementary AD or DDD sequences may be attached to an adaptor module that forms the core of the bioactive assembly, allowing formation of the assembly through the specific DDD/AD binding interactions. Such assemblies may be attached to a wide variety of effector moieties for treatment, detection and/or diagnosis of a disease, pathogen infection or other medical or veterinary condition.
Inventor(s): Chang; Chien-Hsing (Downingtown, PA), Goldenberg; David M. (Mendham, NJ), McBride; William J. (Boonton, NJ), Rossi; Edmund A. (Woodland Park, NJ)
Assignee: IBC Pharmaceuticals, Inc. (Morris Plains, NJ)
Application Number:13/549,906
Patent Claims:see list of patent claims

Details for Patent 8,865,176

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Medimmune SYNAGIS palivizumab VIAL 103770 001 1998-06-19 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 002 1998-06-19 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 RX search
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 RX Orphan search
Genentech XOLAIR omalizumab VIAL 103976 001 2003-06-20 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 RX search
Abbvie Inc HUMIRA adalimumab SYRINGE 125057 001 2002-12-31 ➤ Sign Up IBC Pharmaceuticals, Inc. (Morris Plains, NJ) 2025-10-19 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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