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Last Updated: September 26, 2020

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Patent: 8,859,748

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Summary for Patent: 8,859,748
Title:Nucleic acid amplification primers for PCR-based clonality studies
Abstract: The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V.lamda.-J.lamda. IGL rearrangement, a V.beta.-J.beta. TCRB rearrangement, a D.beta.-J.beta. TCRB rearrangement, a V.gamma.-J.gamma. TCRG rearrangement, a V.delta.-J.delta. TCRD rearrangement, a D.delta.-D.delta. TCRD rearrangement, a D.delta.-J.delta. TCRD rearrangement, a V.delta.-D.delta. TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.
Inventor(s): Van Dongen; Jacobus Johannes Maria (Vorden, NL), Langerak; Anthonie Willem (Barendrecht, NL), Schuuring; Eduardus Maria Dominicus (Groningen, NL), San Miquel; Jesus Fernando (Salamanca, ES), Garcia Sanz; Ramon (Salamanca, ES), Parreira; Antonio (Lisbon, PT), Smith; John Lewis (Wilts, GB), Lavender; Frances Louise (Hants, GB), Morgan; Gareth John (Surrey, GB), Evans; Paul Anthony Stuart (West Yorkshire, GB), Kneba; Michael (Westensee, DE), Hummel; Michael (Berlin, DE), Macintyre; Elizabeth Anne (Meudon, FR), Bastard; Christian (Ardouval, FR)
Application Number:10/531,106
Patent Claims:see list of patent claims

Details for Patent 8,859,748

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Express Scripts
Harvard Business School

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