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Last Updated: September 27, 2020

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Patent: 8,841,267

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Summary for Patent: 8,841,267
Title:Micro-RNA scaffolds, non-naturally occurring micro-RNAs, and methods for optimizing non-naturally occurring micro-RNAs
Abstract: The present disclosure provides non-naturally occurring miR-196a-2 miRNAs and non-naturally occurring miR-204 miRNAs. The non-naturally occurring miRNAs of the disclosure have mature strand sequences distinct from their endogenous counterparts. The disclosure also provides methods of selecting mature strand sequences that function optimally in non-naturally occurring miR-196a-2 miRNAs. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.
Inventor(s): Kelley; Melissa (Lafayette, CO), Birmingham; Amanda (Lafayette, CO), Karpilow; Jon (Boulder, CO), Khvorova; Anastasia (Boulder, CO), Sullivan; Kevin (Boulder, CO)
Assignee: GE Healthcare Dharmacon, Inc. (Lafayette, CO)
Application Number:12/601,506
Patent Claims:see list of patent claims

Details for Patent 8,841,267

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial GE Healthcare Dharmacon, Inc. (Lafayette, CO) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial GE Healthcare Dharmacon, Inc. (Lafayette, CO) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial GE Healthcare Dharmacon, Inc. (Lafayette, CO) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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