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Generated: July 19, 2019

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Patent: 8,829,170

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Summary for Patent: 8,829,170
Title:Construct capable of release in closed circular form from a larger nucleotide sequence permitting site specific expression and/or developmentally regulated expression of selected genetic sequences
Abstract: The present invention relates generally to constructs and in particular genetic constructs comprising polynucleotide sequences capable of release in covalently closed, circular form from a larger nucleotide sequence such as, but not limited to, a genome of a eukaryotic cell. Preferably, once released, a polynucleotide sequence is reconstituted in a form which permits expression of the polynucleotide sequence. In one embodiment, the reconstituted polynucleotide sequence comprises a coding sequence with all or part of an extraneous nucleotide such as, but not limited to, an intronic sequence or other splice signal inserted therein. Expression and in particular transcription of the coding sequence involves splicing out the extraneous sequence. The release and circularization is generally in response to a stimulus such as a protein-mediated stimulus. More particularly, the protein is a viral or prokaryotic or eukaryotic derived protein or developmentally and/or tissue specific regulated protein.
Inventor(s): Dale; James Langham (Anstead, AU), Dugdale; Benjamin (Milton, AU), Hafner; Greg John (Carina, AU), Hermann; Scott Richard (Strathpine, AU), Becker; Douglas Kenneth (Alderley, AU), Harding; Robert Maxwell (Highgate Hill, AU), Chowpongpang; Srimek (Samut, TH)
Assignee: Queensland University of Technology (Brisbane, Queensland, AU)
Application Number:12/948,005
Patent Claims:see list of patent claims

Details for Patent 8,829,170

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up Queensland University of Technology (Brisbane, Queensland, AU) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up Queensland University of Technology (Brisbane, Queensland, AU) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up Queensland University of Technology (Brisbane, Queensland, AU) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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