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Generated: August 24, 2019

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Patent: 8,795,673

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Summary for Patent: 8,795,673
Title:Preparation of maytansinoid antibody conjugates by a one-step process
Abstract: The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.
Inventor(s): Li; Xinfang (Chestnut Hill, MA), Worful; Jared M. (Somerville, MA)
Assignee: ImmunoGen, Inc. (Waltham, MA)
Application Number:13/434,451
Patent Claims:see list of patent claims

Details for Patent 8,795,673

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25 ➤ Sign Up ImmunoGen, Inc. (Waltham, MA) 2031-03-29 RX Orphan search
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26 ➤ Sign Up ImmunoGen, Inc. (Waltham, MA) 2031-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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