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Last Updated: September 20, 2020

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Patent: 8,795,659

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Summary for Patent: 8,795,659
Title:Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
Abstract: The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula I: ##STR00001## (I) wherein A.sup.+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.
Inventor(s): Morgan; Lee R. (New Orleans, LA)
Assignee: Dekk-Tec, Inc. (New Orleans, LA)
Application Number:13/541,522
Patent Claims:see list of patent claims

Details for Patent 8,795,659

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Dekk-Tec, Inc. (New Orleans, LA) 2024-10-25 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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