Flexible Subscriptions to Match your Budget and Timeline See Plans and Pricing

Serving leading biopharmaceutical companies globally:

Medtronic
Harvard Business School
McKinsey
Boehringer Ingelheim
McKesson
AstraZeneca

Last Updated: December 3, 2021

DrugPatentWatch Database Preview

Patent: 8,791,125

➤ Subscribe for complete access

« Back to Dashboard

Summary for Patent: 8,791,125
Title:Dihydropyrazolopyrimidinone derivatives
Abstract: The invention relates to compounds of a general formula (I): ##STR00001## wherein Ar.sup.1 is an optionally-substituted aryl or heteroaromatic group; R.sup.1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R.sup.2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of --N(R.sup.1k)R.sup.1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.
Inventor(s): Sagara; Takeshi (Tsukuba, JP), Otsuki; Sachie (Tsukuba, JP), Sunami; Satoshi (Toride, JP), Sakamoto; Toshihiro (Moriya, JP), Niiyama; Kenji (Tsuchiura, JP), Yamamoto; Fuyuki (Tsukuba, JP), Yoshizumi; Takashi (Ushiku, JP), Furuyama; Hidetomo (Tsukuba, JP), Goto; Yasuhiro (Tsukuba, JP), Bamba; Makoto (Tsukuba, JP), Takahashi; Keiji (Tsukuba, JP), Hirai; Hiroshi (Tsukuba, JP), Nishibata; Toshihide (Tsukuba, JP)
Assignee: MSD K.K. (Chiyoda-Ku, Tokyo, JP)
Application Number:13/053,798
Patent Claims:see list of patent claims

Details for Patent 8,791,125

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genzyme Corporation THYROGEN thyrotropin alfa For Injection 020898 1998-11-30 ⤷  Try it Free 2026-04-27
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 1978-01-10 ⤷  Try it Free 2026-04-27
Clinigen, Inc. PROLEUKIN aldesleukin For Injection 103293 1992-05-05 ⤷  Try it Free 2026-04-27
Genentech, Inc. RITUXAN rituximab Injection 103705 1997-11-26 ⤷  Try it Free 2026-04-27
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 2002-02-19 ⤷  Try it Free 2026-04-27
Eisai, Incorporated ONTAK denileukin diftitox Injection 103767 1999-02-05 ⤷  Try it Free 2026-04-27
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Try it Free 2026-04-27
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Medtronic
McKinsey
McKesson
Express Scripts
Johnson and Johnson
Colorcon

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.