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Last Updated: September 30, 2020

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Patent: 8,784,808

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Summary for Patent: 8,784,808
Title:Fc.gamma.RIIB specific antibodies and methods of use thereof
Abstract: The present invention relates to antibodies or fragments thereof that bind Fc.gamma.RIIB with greater affinity than said antibodies or fragments binds Fc.gamma.RIIA. The invention encompasses the use of such antibodies or fragments for the treatment of diseases related to loss of balance of Fc receptor mediated signaling, such as cancer, autoimmune diseases, inflammatory diseases or IgE-mediated allergic disorders. The present invention also encompasses the use of such antibodies and fragments in combination with other cancer therapies, methods of enhancing the therapeutic effect of therapeutic antibodies, and methods of enhancing efficacy of vaccine compositions.
Inventor(s): Johnson; Leslie S. (Darnestown, MD), Huang; Ling (Bethesda, MD)
Assignee: MacroGenics, Inc. (Rockville, MD)
Application Number:13/367,626
Patent Claims:see list of patent claims

Details for Patent 8,784,808

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 001 1997-11-26   Start Trial MacroGenics, Inc. (Rockville, MD) 2024-05-10 RX search
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 002 1997-11-26   Start Trial MacroGenics, Inc. (Rockville, MD) 2024-05-10 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial MacroGenics, Inc. (Rockville, MD) 2024-05-10 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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