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Last Updated: October 26, 2021

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Patent: 8,747,857

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Summary for Patent: 8,747,857
Title:Calicheamicin derivative-carrier conjugates
Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Inventor(s): Kunz; Arthur (New City, NY), Moran; Justin Keith (Valley Cottage, NY), Rubino; Joseph Thomas (Towaco, NJ), Jain; Neera (New City, NY), Vidunas; Eugene Joseph (Middletown, NY), Simpson; John McLean (Upper Nyack, NY), Merchant; Nishith (Palisades Park, NJ), Dijoseph; John Francis (Woodbridge, NJ), Ruppen; Mark Edward (Garnerville, NY), Damle; Nitin Krishnaji (Upper Saddle River, NJ), Robbins; Paul David (Derwood, MD), Popplewell; Andrew George (Middlesex, GB)
Assignee: Wyeth Holdings LLC (Madison, NJ)
Application Number:10/699,874
Patent Claims:see list of patent claims

Details for Patent 8,747,857

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 1997-11-26 ⤷  Free Forever Trial 2022-05-02
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 2002-02-19 ⤷  Free Forever Trial 2022-05-02
Genentech, Inc. RITUXAN HYCELA rituximab and hyaluronidase human Injection 761064 2017-06-22 ⤷  Free Forever Trial 2022-05-02
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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