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Generated: September 15, 2019

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Patent: 8,747,857

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Summary for Patent: 8,747,857
Title:Calicheamicin derivative-carrier conjugates
Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Inventor(s): Kunz; Arthur (New City, NY), Moran; Justin Keith (Valley Cottage, NY), Rubino; Joseph Thomas (Towaco, NJ), Jain; Neera (New City, NY), Vidunas; Eugene Joseph (Middletown, NY), Simpson; John McLean (Upper Nyack, NY), Merchant; Nishith (Palisades Park, NJ), Dijoseph; John Francis (Woodbridge, NJ), Ruppen; Mark Edward (Garnerville, NY), Damle; Nitin Krishnaji (Upper Saddle River, NJ), Robbins; Paul David (Derwood, MD), Popplewell; Andrew George (Middlesex, GB)
Assignee: Wyeth Holdings LLC (Madison, NJ)
Application Number:10/699,874
Patent Claims:see list of patent claims

Details for Patent 8,747,857

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26 ➤ Sign Up Wyeth Holdings LLC (Madison, NJ) 2022-05-02 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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