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Last Updated: November 28, 2021

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Patent: 8,742,076

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Summary for Patent: 8,742,076
Title:Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
Abstract: The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D).sub.p I where one or more nemorubicin metabolite or analog drug moieties (D) are covalently attached by a linker (L) to an antibody (Ab) which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be useful in methods of diagnosis or treatment of cancer, and other diseases and disorders.
Inventor(s): Cohen; Robert L. (San Mateo, CA), Ha; Edward HyungSuk (San Francisco, CA), Reynolds; Mark E. (Millbrae, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:12/865,354
Patent Claims:see list of patent claims

Details for Patent 8,742,076

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Free Forever Trial 2039-02-26
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Free Forever Trial 2039-02-26
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 2019-02-28 ⤷  Free Forever Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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