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Last Updated: October 1, 2020

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Patent: 8,741,291

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Summary for Patent: 8,741,291
Title:Multifunctional antibody conjugates
Abstract: The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL.kappa.) comprising K.sup.188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K.sup.188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.
Inventor(s): Bhat; Abhijit Suresh (Encinitas, CA), Bradshaw; Curt William (San Diego, CA), Laurent; Olivier Alexandre (San Diego, CA), Lee; Alice (Poway, CA), Preston; Richard Ryan (Escondido, CA), Tumelty; David (San Diego, CA), Wood; Lauren Diane (San Diego, CA), Yu; Wei Hong (San Diego, CA)
Assignee: Covx Technologies Ireland, Limited (Dun Laoghaire County, Dublin, IE)
Application Number:13/305,354
Patent Claims:see list of patent claims

Details for Patent 8,741,291

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 002 2017-06-22   Start Trial Covx Technologies Ireland, Limited (Dun Laoghaire County, Dublin, IE) 2030-07-12 RX Orphan search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 001 2017-06-22   Start Trial Covx Technologies Ireland, Limited (Dun Laoghaire County, Dublin, IE) 2030-07-12 RX Orphan search
Genentech LUCENTIS ranibizumab INJECTABLE; INJECTION 125156 001 2006-06-30   Start Trial Covx Technologies Ireland, Limited (Dun Laoghaire County, Dublin, IE) 2030-07-12 RX search
Biogen Idec TYSABRI natalizumab VIAL; SINGLE-USE 125104 001 2004-11-23   Start Trial Covx Technologies Ireland, Limited (Dun Laoghaire County, Dublin, IE) 2030-07-12 RX search
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial Covx Technologies Ireland, Limited (Dun Laoghaire County, Dublin, IE) 2030-07-12 RX Orphan search
Abbvie Inc HUMIRA adalimumab VIAL 125057 002 2002-12-31   Start Trial Covx Technologies Ireland, Limited (Dun Laoghaire County, Dublin, IE) 2030-07-12 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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