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Last Updated: September 30, 2020

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Patent: 8,734,846

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Summary for Patent: 8,734,846
Title:Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
Abstract: This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This \"polymerization from\" approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a \"coupling to\" that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses \"orthogonal\" chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.
Inventor(s): Ali; Mir M. (Woburn, MA), Hrkach; Jeff (Lexington, MA), Zale; Stephen E. (Hopkinton, MA), Alvarez de Cienfuegos; Luis (Granada, ES)
Assignee: Bind Biosciences, Inc. (Cambridge, MA)
Application Number:13/667,299
Patent Claims:see list of patent claims

Details for Patent 8,734,846

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial Bind Biosciences, Inc. (Cambridge, MA) 2028-06-16 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial Bind Biosciences, Inc. (Cambridge, MA) 2028-06-16 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial Bind Biosciences, Inc. (Cambridge, MA) 2028-06-16 DISCN search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Bind Biosciences, Inc. (Cambridge, MA) 2028-06-16 RX search
Chiron PROLEUKIN aldesleukin VIAL 103293 001 1992-05-05   Start Trial Bind Biosciences, Inc. (Cambridge, MA) 2028-06-16 RX search
Amgen NEUPOGEN filgrastim VIAL 103353 001 1991-02-20   Start Trial Bind Biosciences, Inc. (Cambridge, MA) 2028-06-16 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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