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Last Updated: December 5, 2021

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Patent: 8,734,846

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Summary for Patent: 8,734,846
Title:Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
Abstract: This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This \"polymerization from\" approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a \"coupling to\" that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses \"orthogonal\" chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.
Inventor(s): Ali; Mir M. (Woburn, MA), Hrkach; Jeff (Lexington, MA), Zale; Stephen E. (Hopkinton, MA), Alvarez de Cienfuegos; Luis (Granada, ES)
Assignee: Bind Biosciences, Inc. (Cambridge, MA)
Application Number:13/667,299
Patent Claims:see list of patent claims

Details for Patent 8,734,846

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Microbix Biosystems Inc. KINLYTIC urokinase For Injection 021846 1978-01-16 ⤷  Try it Free 2028-06-16
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 1978-01-10 ⤷  Try it Free 2028-06-16
Clinigen, Inc. PROLEUKIN aldesleukin For Injection 103293 1992-05-05 ⤷  Try it Free 2028-06-16
Amgen, Inc. NEUPOGEN filgrastim Injection 103353 1991-02-20 ⤷  Try it Free 2028-06-16
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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