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Last Updated: September 25, 2020

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Patent: 8,716,557

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Summary for Patent: 8,716,557
Title:Compositions and methods for inhibition of fucosyltransferase and xylosyltransferase expression in plants
Abstract: Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant RNAi construct that provides for the inhibition of expression of .alpha.1,3-fucosyltransferase (FucT) and .beta.1,2-xylosyltransferase (XylT) in a plant. Use of these RNAi constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a \"humanized\" N-glycosylation pattern without impacting plant growth and development. Stably transformed higher plants having this protein N-glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the G0 glycoform, are also provided.
Inventor(s): Dickey; Lynn F. (Cary, NC), Cox; Kevin M. (Raleigh, NC), Peele; Charles G. (Apex, NC), Wang; Ming-Bo (Canberra, AU)
Assignee: Synthon Biopharmaceuticals B.V. (Nijmegen, NL)
Application Number:11/624,158
Patent Claims:see list of patent claims

Details for Patent 8,716,557

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Synthon Biopharmaceuticals B.V. (Nijmegen, NL) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Synthon Biopharmaceuticals B.V. (Nijmegen, NL) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Synthon Biopharmaceuticals B.V. (Nijmegen, NL) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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