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Last Updated: December 5, 2021

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Patent: 8,715,665

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Summary for Patent: 8,715,665
Title:Methods for treating cancer resistant to ErbB therapeutics
Abstract: Provided herein are methods for treating cancer that is resistant to treatment with an anti-ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti-ErbB therapeutic and an anti-MET therapeutic. Also provided are methods for reducing ErbB mediated signaling or PI3 kinase mediated signaling in a cancer cell.
Inventor(s): Janne; Pasi A. (Newton, MA), Engelman; Jeffrey (Chestnut Hill, MA), Cantley; Lewis C. (Cambridge, MA)
Assignee: The General Hospital Corporation (Boston, MA) Dana Farber Cancer Institute (Boston, MA) Beth Israel Deaconess Medical Center (Boston, MA)
Application Number:12/450,826
Patent Claims:see list of patent claims

Details for Patent 8,715,665

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Try it Free 2027-04-13
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Try it Free 2027-04-13
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2004-02-12 ⤷  Try it Free 2027-04-13
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2007-03-28 ⤷  Try it Free 2027-04-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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