Patent: 8,697,747
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Summary for Patent: 8,697,747
| Title: | Enhancing coagulation or reducing fibrinolysis |
| Abstract: | Methods for controlling bleeding (e.g., enhancing coagulation and reducing fibrinolysis) in a subject are disclosed. The methods include selecting a subject in need of enhanced coagulation or reduced fibrinolysis, and administering to the subject a carbon monoxide releasing molecule (CORM). Examples of CORMs include tricarbonyldichloro-ruthenium (II) dimer, tricarbonylchloro-(glycinato)ruthenium (II), sodium boranocarbonate, dimanganese decacarbonyl, and iron pentacarbonyl. Further disclosed are compositions and methods for treating a subject in need of a blood product by administering to the subject a composition including a CORM and a blood product (e.g., cryoprecipitate or fresh frozen plasma). |
| Inventor(s): | Nielsen; Vance G. (Moorestown, NJ), George; James F. (Birmingham, AL), Kirklin; James K. (Birmingham, AL) |
| Assignee: | THe UAB Research Foundation (Birmingham, AL) |
| Application Number: | 13/254,287 |
| Patent Claims: | see list of patent claims |
Details for Patent 8,697,747
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Baxalta Us Inc. | AUTOPLEX, FEIBA NF, FEIBA VH | anti-inhibitor coagulant complex | For Injection | 101447 | 12/21/1979 | ⤷ Try a Trial | 2029-03-05 |
| Baxalta Us Inc. | AUTOPLEX, FEIBA NF, FEIBA VH | anti-inhibitor coagulant complex | For Injection | 101447 | 07/31/2000 | ⤷ Try a Trial | 2029-03-05 |
| Baxalta Us Inc. | AUTOPLEX, FEIBA NF, FEIBA VH | anti-inhibitor coagulant complex | For Injection | 101447 | 08/11/2005 | ⤷ Try a Trial | 2029-03-05 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
