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Last Updated: October 1, 2020

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Patent: 8,697,080

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Summary for Patent: 8,697,080
Title:Methods and compositions for treatment of human immunodeficiency virus infection with conjugated antibodies or antibody fragments
Abstract: The present invention concerns methods and compositions for treatment of HIV infection in a subject. The compositions may comprise a targeting molecule against an HIV antigen, such as an anti-HIV antibody or antibody fragment. The anti-HIV antibody or fragment may be conjugated to a variety of cytotoxic agents, such as doxorubicin. In a preferred embodiment, the antibody or fragment is P4/D10. Other embodiments may concern methods of imaging, detection or diagnosis of HIV infection in a subject using an anti-HIV antibody or fragment conjugated to a diagnostic agent. In alternative embodiments, a bispecific antibody with at least one binding site for an HIV antigen and at least one binding site for a carrier molecule may be administered, optionally followed by a clearing agent, followed by administration of a carrier molecule conjugated to a therapeutic agent.
Inventor(s): Goldenberg; David M. (Mendham, NJ), Chang; Chien-Hsing (Downingtown, PA), Rossi; Edmund A. (Morris Plains, NJ), McBride; William J. (Boonton, NJ)
Assignee: Immunomedics Inc. (Morris Plains, NJ)
Application Number:13/675,422
Patent Claims:see list of patent claims

Details for Patent 8,697,080

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial Immunomedics Inc. (Morris Plains, NJ) 2026-05-15 search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Immunomedics Inc. (Morris Plains, NJ) 2026-05-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 8,697,080

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