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Last Updated: December 5, 2021

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Patent: 8,691,225

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Summary for Patent: 8,691,225
Title:Antibodies against the ectodomain of ErbB3 and uses thereof
Abstract: The present invention provides a novel class of antibodies and antigen binding fragments thereof that bind the extracellular domain of ErbB3 receptor and inhibit various ErbB3 functions. For example, the antibodies and antigen binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor. Such antibodies and antigen binding fragments thereof have the useful characteristic of inhibiting the proliferation of cancer cells expressing ErbB3.
Inventor(s): Schoeberl; Birgit (Cambridge, MA), Nielsen; Ulrik (Quincy, MA), Feldhaus; Michael (Grantham, NH), Muruganandam; Arumugam (Bangalore, IN), Buckler; David (Chester, NJ)
Assignee: Merrimack Pharmaceuticals, Inc. (Cambridge, MA)
Application Number:12/545,279
Patent Claims:see list of patent claims

Details for Patent 8,691,225

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Try it Free 2027-02-16
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Try it Free 2027-02-16
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2004-02-12 ⤷  Try it Free 2027-02-16
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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