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Last Updated: October 1, 2020

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Patent: 8,673,924

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Summary for Patent: 8,673,924
Title:Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
Abstract: In its many embodiments, the present invention provides a method of inhibiting one or more cyclin dependent kinases in a patient comprising administering to said patient a therapeutically effective amount of at least one pyrazolo[1,5-a]pyrimidine compound or a pharmaceutical composition comprising such compound, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions. An example pyrazolo[1,5-a]pyrimidine compound useful in the present invention is shown below: ##STR00001##
Inventor(s): Guzi; Timothy J. (Chatham, NJ), Paruch; Kamil (Garwood, NJ), Dwyer; Michael P. (Scotch Plains, NJ), Doll; Ronald J. (Convent Station, NJ), Girijavallabhan; Viyyoor M. (Parsippany, NJ), Mallams; Alan (Hackettstown, NJ), Alvarez; Carmen S. (Livingston, NJ), Keertikar; Kartik M. (East Windsor, NJ), Rivera; Jocelyn (Monmouth Junction, NJ), Chan; Tin-Yau (Edison, NJ), Madison; Vincent S. (Mountain Lakes, NJ), Fischmann; Thierry O. (Scotch Plains, NJ), Dillard; Lawrence W. (Skillman, NJ), Tran; Vinh D. (Fountain Valley, CA), He; Zhenmin (Shanghai, CN), James; Ray Anthony (Bensalem, PA), Park; Haengsoon (Plainsboro, NJ), Paradkar; Vidyadhar M. (Somerville, NJ), Hobbs; Douglas Walsh (Yardley, PA), Kirschmeier; Paul (Basking Ridge, NJ), Bannerji; Rajat (Morristown, NJ)
Assignee: Merck Sharp & Dohme Corp. (Rahway, NJ) Pharmacopeia, LLC (San Diego, CA)
Application Number:11/788,847
Patent Claims:see list of patent claims

Details for Patent 8,673,924

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial Merck Sharp & Dohme Corp. (Rahway, NJ) Pharmacopeia, LLC (San Diego, CA) 2022-09-04 RX search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 002 2017-06-22   Start Trial Merck Sharp & Dohme Corp. (Rahway, NJ) Pharmacopeia, LLC (San Diego, CA) 2022-09-04 RX Orphan search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 001 2017-06-22   Start Trial Merck Sharp & Dohme Corp. (Rahway, NJ) Pharmacopeia, LLC (San Diego, CA) 2022-09-04 RX Orphan search
Wyeth Pharms Inc MYLOTARG gemtuzumab ozogamicin VIAL;SINGLE-DOSE 761060 001 2018-04-09   Start Trial Merck Sharp & Dohme Corp. (Rahway, NJ) Pharmacopeia, LLC (San Diego, CA) 2022-09-04 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26   Start Trial Merck Sharp & Dohme Corp. (Rahway, NJ) Pharmacopeia, LLC (San Diego, CA) 2022-09-04 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

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