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Generated: July 21, 2019

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Patent: 8,663,643

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Summary for Patent: 8,663,643
Title:Combinations of an anti-HER2 antibody-drug conjugate and chemotherapeutic agents, and methods of use
Abstract: Combinations of the antibody-drug conjugate trastuzumab-MCC-DM1 and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting tumor cell growth, and for treating disorders such as cancer mediated by HER2 and KDR (VEGFR receptor 1). Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Inventor(s): Berry; Leanne (South San Francisco, CA), Phillips; Gail Lewis (San Carlos, CA), Sliwkowski; Mark X. (San Carlos, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:12/400,988
Patent Claims:see list of patent claims

Details for Patent 8,663,643

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25 ➤ Sign Up Genentech, Inc. (South San Francisco, CA) ➤ Sign Up RX Orphan search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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