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Last Updated: October 26, 2021

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Patent: 8,658,608

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Summary for Patent: 8,658,608
Title:Modified triple-helix forming oligonucleotides for targeted mutagenesis
Abstract: High affinity, chemically modified triplex-forming oligonucleotides (TFOs) and methods for use thereof are disclosed. TFOs are defined as triplex-forming oligonucleotides which bind as third strands to duplex DNA in a sequence specific manner. Triplex-forming oligonucleotides may be comprised of any possible combination of nucleotides and modified nucleotides. Modified nucleotides may contain chemical modifications of the heterocyclic base, sugar moiety or phosphate moiety. A high affinity oligonucleotide (K.sub.d.ltoreq.2.times.10.sup.-8) which forms a triple strand with a specific DNA segment of a target gene DNA is generated. It is preferable that the K.sub.d for the high affinity oligonucleotide is below 2.times.10.sup.-10. The nucleotide binds or hybridizes to a target sequence within a target gene or target region of a chromosome, forming a triplex region. The binding of the oligonucleotide to the target region stimulates mutations within or adjacent to the target region using cellular DNA synthesis, recombination, and repair mechanisms. The mutation generated activates, inactivates, or alters the activity and function of the target gene.
Inventor(s): Glazer; Peter M. (Guilford, CT), Siedman; Michael M. (Washington, DC)
Assignee: Yale University (New Haven, CT) Department of Health and Human Services (Washington, DC)
Application Number:11/562,849
Patent Claims:see list of patent claims

Details for Patent 8,658,608

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Free Forever Trial 2025-11-23
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Free Forever Trial 2025-11-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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