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Generated: July 17, 2019

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Patent: 8,652,484

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Summary for Patent: 8,652,484
Title:Delivery system for cytotoxic drugs by bispecific antibody pretargeting
Abstract: The present invention relates to methods and compositions for pretargeting delivery of therapeutic agents. In preferred embodiments, the pretargeting method comprises: a) administering a bispecific antibody with a first binding site for a disease-associated antigen and a hapten on a targetable construct; b) administering a targetable construct comprising at least one therapeutic agent. In preferred embodiments, the bispecific antibody is made by the dock-and-lock (DNL) technique. In a more preferred embodiment, the targetable construct comprises one or more SN-38 moieties.
Inventor(s): McBride; William J. (Boonton, NJ), D\'Souza; Christopher A. (Pomona, NY), Chang; Chien-Hsing (Downington, PA), Goldenberg; David M. (Mendham, NJ)
Assignee: Immunomedics, Inc. (Morris Plains, NJ)
Application Number:13/710,908
Patent Claims:see list of patent claims

Details for Patent 8,652,484

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ➤ Sign Up Immunomedics, Inc. (Morris Plains, NJ) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 8,652,484

Country Patent Number Publication Date
United States of America 6183744 Feb 06, 2001
United States of America 6306393 Oct 23, 2001
United States of America 6761680 Jul 13, 2004
United States of America 6786858 Sep 07, 2004
United States of America 6820318 Nov 23, 2004
United States of America 6997862 Feb 14, 2006
United States of America 7008368 Mar 07, 2006
Country Patent Number Publication Date

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