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Generated: September 22, 2019

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Patent: 8,642,737

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Summary for Patent: 8,642,737

Title:	Nucleophilic catalysts for oxime linkage
Abstract:	The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
Inventor(s):	Siekmann; Juergen (Vienna, AT), Haider; Stefan (Prinzersdorf, AT), Rottensteiner; Hanspeter (Vienna, AT), Ivens; Andreas (Zurich, CH), Turecek; Peter (Klosterneuburg, AT), Zoechling; Oliver (Vienna, AT)
Assignee:	Baxter International Inc. (Deerfield, IL) Baxter Healthcare SA (Glattpark (Opfikon), CH)
Application Number:	13/194,038
Patent Claims:	see list of patent claims

Details for Patent 8,642,737

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Immunex	ENBREL	etanercept	VIAL; SUBCUTANEOUS	103795	001	1998-11-02	Try a Free Trial	Baxter International Inc. (Deerfield, IL) Baxter Healthcare SA (Glattpark (Opfikon), CH)	2036-04-30	RX	Orphan	search
Immunex	ENBREL	etanercept	SYRINGE	103795	002	1998-11-02	Try a Free Trial	Baxter International Inc. (Deerfield, IL) Baxter Healthcare SA (Glattpark (Opfikon), CH)	2036-04-30	RX	Orphan	search
Abbvie Inc	HUMIRA	adalimumab	SYRINGE	125057	001	2002-12-31	Try a Free Trial	Baxter International Inc. (Deerfield, IL) Baxter Healthcare SA (Glattpark (Opfikon), CH)	2036-04-30	RX		search
Abbvie Inc	HUMIRA	adalimumab	VIAL	125057	002	2002-12-31	Try a Free Trial	Baxter International Inc. (Deerfield, IL) Baxter Healthcare SA (Glattpark (Opfikon), CH)	2036-04-30	RX		search
Amgen	PROLIA	denosumab	INJECTABLE; SUBCUTANEOUS	125320	001	2010-06-01	Try a Free Trial	Baxter International Inc. (Deerfield, IL) Baxter Healthcare SA (Glattpark (Opfikon), CH)	2036-04-30	RX	Orphan	search
Amgen	XGEVA	denosumab	INJECTABLE; SUBCUTANEOUS	125320	002	2010-06-01	Try a Free Trial	Baxter International Inc. (Deerfield, IL) Baxter Healthcare SA (Glattpark (Opfikon), CH)	2036-04-30	RX	Orphan	search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 8,642,737

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Country	Patent Number	Publication Date
Argentina	077600	Sep 07, 2011
Argentina	082941	Jan 23, 2013
Argentina	084576	May 29, 2013
Australia	2010277438	Aug 20, 2015
Australia	2010277438	Feb 09, 2012
Australia	2010281453	Mar 01, 2012
>Country	>Patent Number	>Publication Date

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