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Last Updated: January 23, 2021

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Patent: 8,642,314

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Summary for Patent: 8,642,314

Title:	Optimization of expression of parvoviral rep and cap proteins in insect cells
Abstract:	The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral Rep proteins that increase the productivity of parvoviral vectors.
Inventor(s):	Bakker; Andrew Christian (Almere, NL), Hermens; Wilhelmus Theodorus Johannes Maria Christiaan (Almere, NL), Noordman; Yvet (Utrecht, NL)
Assignee:	Amsterdam Molecular Therapeutics (AMT) B.V. (NL)
Application Number:	12/918,460
Patent Claims:	see list of patent claims

Details for Patent 8,642,314

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Schering	INTRON A	interferon alfa-2b	VIAL	103132	003	1986-06-04	Start Trial	Amsterdam Molecular Therapeutics (AMT) B.V. (NL)	2028-02-19	RX		search
Schering	INTRON A	interferon alfa-2b	VIAL	103132	002	1986-06-04	Start Trial	Amsterdam Molecular Therapeutics (AMT) B.V. (NL)	2028-02-19	RX		search
Schering	INTRON A	interferon alfa-2b	VIAL	103132	001	1986-06-04	Start Trial	Amsterdam Molecular Therapeutics (AMT) B.V. (NL)	2028-02-19	RX		search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 8,642,314

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2009104964	Start Trial
United States of America	2011136227	Start Trial
United States of America	2014127801	Start Trial
United States of America	9260724	Start Trial
>Country	>Patent Number	>Estimated Expiration

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