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Patent: 8,642,314
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Summary for Patent: 8,642,314
Title: | Optimization of expression of parvoviral rep and cap proteins in insect cells |
Abstract: | The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral Rep proteins that increase the productivity of parvoviral vectors. |
Inventor(s): | Bakker; Andrew Christian (Almere, NL), Hermens; Wilhelmus Theodorus Johannes Maria Christiaan (Almere, NL), Noordman; Yvet (Utrecht, NL) |
Assignee: | Amsterdam Molecular Therapeutics (AMT) B.V. (NL) |
Application Number: | 12/918,460 |
Patent Claims: | see list of patent claims |
Details for Patent 8,642,314
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Schering | INTRON A | interferon alfa-2b | VIAL | 103132 | 003 | 1986-06-04 | Start Trial | Amsterdam Molecular Therapeutics (AMT) B.V. (NL) | 2028-02-19 | RX | search | |
Schering | INTRON A | interferon alfa-2b | VIAL | 103132 | 002 | 1986-06-04 | Start Trial | Amsterdam Molecular Therapeutics (AMT) B.V. (NL) | 2028-02-19 | RX | search | |
Schering | INTRON A | interferon alfa-2b | VIAL | 103132 | 001 | 1986-06-04 | Start Trial | Amsterdam Molecular Therapeutics (AMT) B.V. (NL) | 2028-02-19 | RX | search | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 8,642,314
Country | Patent Number | Estimated Expiration |
---|---|---|
World Intellectual Property Organization (WIPO) | 2009104964 | Start Trial |
United States of America | 2011136227 | Start Trial |
United States of America | 2014127801 | Start Trial |
United States of America | 9260724 | Start Trial |
>Country | >Patent Number | >Estimated Expiration |