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Generated: July 18, 2019

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Patent: 8,624,079

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Summary for Patent: 8,624,079
Title:Knockin mouse with a disruption in a PXR gene expressing human PXR
Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.
Inventor(s): Wolf; Charles Roland (Dundee, GB), Scheer; Nico (Cologne, DE)
Assignee: ITI Scotland Limited (Glasgow, GB)
Application Number:12/602,723
Patent Claims:see list of patent claims

Details for Patent 8,624,079

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Try a Free Trial ITI Scotland Limited (Glasgow, GB) ➤ Try a Free Trial RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Try a Free Trial ITI Scotland Limited (Glasgow, GB) ➤ Try a Free Trial RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Try a Free Trial ITI Scotland Limited (Glasgow, GB) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 8,624,079

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2006064197 Jun 22, 2006
World Intellectual Property Organization (WIPO) 2006064197 Sep 28, 2006
World Intellectual Property Organization (WIPO) 2008149080 Dec 11, 2008
United States of America 2008148416 Jun 19, 2008
United States of America 2010235928 Sep 16, 2010
Country Patent Number Publication Date

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Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim
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Colorcon
Medtronic
Citi
Johnson and Johnson

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