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Last Updated: February 28, 2020

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Patent: 8,624,079

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Summary for Patent: 8,624,079
Title:Knockin mouse with a disruption in a PXR gene expressing human PXR
Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.
Inventor(s): Wolf; Charles Roland (Dundee, GB), Scheer; Nico (Cologne, DE)
Assignee: ITI Scotland Limited (Glasgow, GB)
Application Number:12/602,723
Patent Claims:see list of patent claims

Details for Patent 8,624,079

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial ITI Scotland Limited (Glasgow, GB) 2027-06-04 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial ITI Scotland Limited (Glasgow, GB) 2027-06-04 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial ITI Scotland Limited (Glasgow, GB) 2027-06-04 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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