Patent: 8,617,840

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Summary for Patent: 8,617,840

Title:	Lysis/resealing process and device for incorporating an active ingredient, in particular asparaginase or inositol hexaphosphate, in erythrocytes
Abstract:	Lysis/resealing process for preparing erythrocytes which contain an active ingredient (e.g. aspariginase or inositol hexaphosphate), the process comprising the following steps: (1) placing a globular concentrate in suspension in an isotonic solution having a haematocrit level which is equal to or greater than 65%, with refrigeration at from +1 to +8.degree. C., (2) measuring the osmotic fragility based on a sample of erythrocytes from that same globular concentrate, preferably on a sample of the suspension obtained in step (1), (3) lysis and internalization procedure of the active ingredient, inside the same chamber, at a temperature which is constantly maintained at from +1 to +8.degree. C., comprising allowing the erythrocyte suspension having a haematocrit level which is equal to or greater than 65% and a hypotonic lysis solution which is refrigerated at from +1 to +8.degree. C. to circulate in a dialysis cartridge; the lysis parameters being adjusted in accordance with the osmotic fragility previously measured; and (4) resealing procedure carried out in a second chamber at a temperature of from +30 to +40.degree. C. by means of a hypertonic solution.
Inventor(s):	Godfrin; Yann (Lyons, FR)
Assignee:	Erytech Pharma (Lyons, FR)
Application Number:	11/573,093
Patent Claims:	see list of patent claims

Details for Patent 8,617,840

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Merck	ELSPAR	asparaginase	VIAL	101063	001	1978-01-10	➤ Sign Up	Erytech Pharma (Lyons, FR)	2024-08-05	RX		search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 8,617,840

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Country	Patent Number	Publication Date
Austria	532504	Nov 15, 2011
Australia	2005270977	Feb 16, 2006
Australia	2005270977	Nov 24, 2011
>Country	>Patent Number	>Publication Date

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