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Last Updated: September 28, 2020

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Patent: 8,614,228

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Summary for Patent: 8,614,228
Title:Quinone prodrug compositions and methods of use
Abstract: The present invention relates to quinone prodrug compositions and therapeutic methods using such prodrug compositions. Preferably, the quinone compounds of the invention are napthoquinone compounds such as .beta.-lapachone or .beta.-lapachone analogs. The quinone prodrug compositions of the invention exhibit improved solubility, stability, bioavailability, and pharmacokinetic properties, as well as improved plasma half-life in vivo.
Inventor(s): Ashwell; Mark A. (Carlisle, MA), Tandon; Manish (Framingham, MA), Lapierre; Jean-Marc (Pelham, NH), Liu; Yanbin (Acton, MA)
Assignee: ArQule, Inc. (Woburn, MA)
Application Number:11/201,170
Patent Claims:see list of patent claims

Details for Patent 8,614,228

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial ArQule, Inc. (Woburn, MA) 2024-08-11 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial ArQule, Inc. (Woburn, MA) 2024-08-11 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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