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Generated: July 16, 2019

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Patent: 8,603,479

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Summary for Patent: 8,603,479
Title:Class I anti-CEA antibodies and uses thereof
Abstract: The present invention provides compositions and methods of use of humanized, chimeric or human Class I anti-CEA antibodies or fragments thereof, preferably comprising the light chain variable region CDR sequences SASSRVSYIH (SEQ ID NO:1); GTSTLAS (SEQ ID NO:2); and QQWSYNPPT (SEQ ID NO:3); and the heavy chain variable region CDR sequences DYYMS (SEQ ID NO:4); FIANKANGHTTDYSPSVKG (SEQ ID NO:5); and DMGIRWNFDV (SEQ ID NO:6). The Class I anti-CEA antibodies or fragments are useful for treating diseases, such as cancer, wherein the diseased cells express CEACAM5 and/or CEACAM6 antigens. The Class I anti-CEA antibodies or fragments are also of use for interfering with specific processes, such as metastasis, invasiveness and/or adhesion of cancer cells, or for enhancing sensitivity of cancer cells to cytotoxic agents and have favorable effects on the survival of subjects with cancer.
Inventor(s): Hansen; Hans J. (Picayune, MS), Chang; Chien-Hsing (Downingtown, PA), Goldenberg; David M. (Mendham, NJ)
Assignee: Immunomedics, Inc. (Morris Plains, NJ)
Application Number:13/898,992
Patent Claims:see list of patent claims

Details for Patent 8,603,479

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ➤ Try a Free Trial Immunomedics, Inc. (Morris Plains, NJ) ➤ Try a Free Trial RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Try a Free Trial Immunomedics, Inc. (Morris Plains, NJ) ➤ Try a Free Trial RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Try a Free Trial Immunomedics, Inc. (Morris Plains, NJ) ➤ Try a Free Trial RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ➤ Try a Free Trial Immunomedics, Inc. (Morris Plains, NJ) ➤ Try a Free Trial RX Orphan search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ➤ Try a Free Trial Immunomedics, Inc. (Morris Plains, NJ) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 8,603,479

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2011034660 Mar 24, 2011
United States of America 2011064653 Mar 17, 2011
United States of America 2013034492 Feb 07, 2013
United States of America 2013344071 Dec 26, 2013
United States of America 2014079629 Mar 20, 2014
United States of America 2014308278 Oct 16, 2014
Country Patent Number Publication Date

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QuintilesIMS
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Queensland Health
Boehringer Ingelheim

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