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Last Updated: December 5, 2021

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Patent: 8,603,014

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Summary for Patent: 8,603,014
Title:Hands-free operator-independent transcranial ultrasound apparatus and methods
Abstract: Disclosed is a \"hands-free\", autonomously operating, battery-powered apparatus with electronic programmable actuation circuitry for non-invasive ultrasonic treatment of ischemic stroke, microatheromas of the cerebral vasculature, intracranial hypertension, and other cerebrovascular pathologies such as hypoperfusion associated with migraine. The apparatus is provided with registration members to facilitate stereotactic placement of the headset on the skull with respect to target intracranial anatomy. Once fitted in place on the skull and activated, the device does not require clinical intervention during operation; does not need skilled technical adjustment of the waveform patterns; and achieves therapeutic results with power consumption of less than 400 mAmp-hr, thus permitting extended portable operation without external power and eliminating the need for assisted cooling. Using a device of the invention, transcranial ultrasound may be self-administered. The device has application in therapeutic methods, such as methods for treating stroke or migraine, for non-invasively augmenting drug action, and for release or dispersal of endogenous neurovascular mediators.
Inventor(s): Alleman; Anthony John (Sherwood, OR), Barnard; William (Maple Valley, WA), Radford; Randal Lee (Burien, WA)
Assignee: Cerevast Therapeutics, Inc. (Redmond, WA)
Application Number:13/209,408
Patent Claims:see list of patent claims

Details for Patent 8,603,014

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Microbix Biosystems Inc. KINLYTIC urokinase For Injection 021846 1978-01-16 ⤷  Try it Free 2039-02-26
Genentech, Inc. ACTIVASE alteplase For Injection 103172 1987-11-13 ⤷  Try it Free 2039-02-26
Genentech, Inc. CATHFLO ACTIVASE alteplase For Injection 103172 2001-09-04 ⤷  Try it Free 2039-02-26
Chiesi Usa, Inc. RETAVASE reteplase For Injection 103786 1996-10-30 ⤷  Try it Free 2039-02-26
Genentech, Inc. TNKASE tenecteplase For Injection 103909 2000-06-02 ⤷  Try it Free 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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