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Last Updated: September 22, 2023

Patent: 8,597,655

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Summary for Patent: 8,597,655
Title:Recombinant fusion protein and polynucleotide construct for immunotoxin production
Abstract: The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.
Inventor(s): Barnea; Itay (Yavne, IL), Benhar; Itai (Rehovot, IL), Ben-Yosef; Rahamim (Mevaseret-Zion, IL), Vexler; Akiva (Hod Hasharon, IL)
Assignee: Ramot at Tel-Aviv University Ltd. (Tel Aviv, IL) The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center (Tel Aviv, IL) N/A (N/A)
Application Number:13/239,847
Patent Claims:see list of patent claims

Details for Patent 8,597,655

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Eli Lilly And Company ERBITUX cetuximab Injection 125084 02/12/2004 ⤷  Try a Trial 2027-05-10
Eli Lilly And Company ERBITUX cetuximab Injection 125084 03/28/2007 ⤷  Try a Trial 2027-05-10
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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