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Last Updated: September 22, 2023

Patent: 8,597,655

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Summary for Patent: 8,597,655

Title:	Recombinant fusion protein and polynucleotide construct for immunotoxin production
Abstract:	The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.
Inventor(s):	Barnea; Itay (Yavne, IL), Benhar; Itai (Rehovot, IL), Ben-Yosef; Rahamim (Mevaseret-Zion, IL), Vexler; Akiva (Hod Hasharon, IL)
Assignee:	Ramot at Tel-Aviv University Ltd. (Tel Aviv, IL) The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center (Tel Aviv, IL) N/A (N/A)
Application Number:	13/239,847
Patent Claims:	see list of patent claims

Details for Patent 8,597,655

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	02/12/2004	⤷ Try a Trial	2027-05-10
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	03/28/2007	⤷ Try a Trial	2027-05-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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