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Last Updated: September 18, 2020

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Patent: 8,591,892

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Summary for Patent: 8,591,892
Title:FTY720 increases CD74 expression and sensitizes cancer cells to anti-CD74 antibody-mediated cell death
Abstract: Disclosed herein are methods and compositions comprising fingolimod and anti-CD74 antibodies or fragments thereof. In preferred embodiments, the fingolimod increases the expression of CD74 in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 antibodies. The compositions and methods are of use to treat diseases involving CD74.sup.+ cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.
Inventor(s): Alinari; Lapo (Dublin, OH), Baiocchi; Robert A. (Dublin, OH), Muthusamy; Natarajan (Galloway, OH), Hansen; Hans J. (Picayune, MS), Goldenberg; David M. (Mendham, NJ)
Assignee: The Ohio State University (Columbus, OH) Immunomedics, Inc. (Morris Plains, NJ)
Application Number:13/551,866
Patent Claims:see list of patent claims

Details for Patent 8,591,892

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial The Ohio State University (Columbus, OH) Immunomedics, Inc. (Morris Plains, NJ) 2031-07-18 RX search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial The Ohio State University (Columbus, OH) Immunomedics, Inc. (Morris Plains, NJ) 2031-07-18 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial The Ohio State University (Columbus, OH) Immunomedics, Inc. (Morris Plains, NJ) 2031-07-18 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial The Ohio State University (Columbus, OH) Immunomedics, Inc. (Morris Plains, NJ) 2031-07-18 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial The Ohio State University (Columbus, OH) Immunomedics, Inc. (Morris Plains, NJ) 2031-07-18 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

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AstraZeneca
Boehringer Ingelheim
Johnson and Johnson

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