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Serving leading biopharmaceutical companies globally:

Express Scripts
Harvard Business School

Last Updated: December 6, 2021

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Patent: 8,591,892

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Summary for Patent: 8,591,892
Title:FTY720 increases CD74 expression and sensitizes cancer cells to anti-CD74 antibody-mediated cell death
Abstract: Disclosed herein are methods and compositions comprising fingolimod and anti-CD74 antibodies or fragments thereof. In preferred embodiments, the fingolimod increases the expression of CD74 in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 antibodies. The compositions and methods are of use to treat diseases involving CD74.sup.+ cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.
Inventor(s): Alinari; Lapo (Dublin, OH), Baiocchi; Robert A. (Dublin, OH), Muthusamy; Natarajan (Galloway, OH), Hansen; Hans J. (Picayune, MS), Goldenberg; David M. (Mendham, NJ)
Assignee: The Ohio State University (Columbus, OH) Immunomedics, Inc. (Morris Plains, NJ)
Application Number:13/551,866
Patent Claims:see list of patent claims

Details for Patent 8,591,892

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 1978-01-10 ⤷  Free Forever Trial 2031-07-18
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 2015-01-23 ⤷  Free Forever Trial 2031-07-18
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Express Scripts
Boehringer Ingelheim
Johnson and Johnson

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