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Last Updated: October 18, 2021

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Patent: 8,580,252

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Summary for Patent: 8,580,252
Title:Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
Abstract: The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated form of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Inventor(s): Bookbinder; Louis H. (San Diego, CA), Kundu; Anirban (San Diego, CA), Frost; Gregory I. (Del Mar, CA)
Assignee: Halozyme, Inc. (San Diego, CA)
Application Number:13/507,540
Patent Claims:see list of patent claims

Details for Patent 8,580,252

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 2019-02-28 ⤷  Free Forever Trial Halozyme, Inc. (San Diego, CA) 2023-03-05 RX search
Genentech Inc RITUXAN HYCELA rituximab; hyaluronidase (human recombinant) SOLUTION;SUBCUTANEOUS 761064 2017-06-22 ⤷  Free Forever Trial Halozyme, Inc. (San Diego, CA) 2023-03-05 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 2004-02-26 ⤷  Free Forever Trial Halozyme, Inc. (San Diego, CA) 2023-03-05 RX Orphan search
Spectrum Pharms ZEVALIN ibritumomab tiuxetan INJECTABLE; INJECTION 125019 2002-02-19 ⤷  Free Forever Trial Halozyme, Inc. (San Diego, CA) 2023-03-05 RX Orphan search
Genzyme LEMTRADA alemtuzumab INJECTABLE;INJECTION 103948 2001-05-07 ⤷  Free Forever Trial Halozyme, Inc. (San Diego, CA) 2023-03-05 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 8,580,252

Country Patent Number Estimated Expiration
South Africa 200507978 ⤷  Free Forever Trial
South Africa 200707898 ⤷  Free Forever Trial
World Intellectual Property Organization (WIPO) 2004078140 ⤷  Free Forever Trial
World Intellectual Property Organization (WIPO) 2006091871 ⤷  Free Forever Trial
United States of America 10016491 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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