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Last Updated: November 28, 2021

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Patent: 8,568,979

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Summary for Patent: 8,568,979
Title:Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization
Abstract: The invention provides a method of selecting a representational sample of nucleic acid sequences from a complex mixture. The method includes: (a) contacting a complex mixture of nucleic acids under conditions sufficient for hybridization with a population of capture probes complementary to one or more nucleic acids comprising a predetermined portion of the sequence collectively present in the complex mixture to form hybridization complexes of the one or more nucleic acids with the population of probes, the population of capture probes being attached to a solid support, and (b) removing unhybridized nucleic acids to select a representational sample of nucleic acids having a complexity of less than 10% but more than 0.001% of the complex mixture, wherein the representational sample comprises a nucleic acid copy having a proportion of each sequence in the copy relative to all other sequences in the copy substantially the same as the proportions of the sequences in the predetermined portion of one or more nucleic acids within the complex mixture.
Inventor(s): Stuelpnagel; John R. (Santa Barbara, CA), Barker; David L. (Del Mar, CA), Velarde, Jr.; Jorge (San Diego, CA), Bernard; Steven M. (San Diego, CA), Graige; Michael (San Diego, CA)
Assignee: Illumina, Inc. (San Diego, CA)
Application Number:12/445,069
Patent Claims:see list of patent claims

Details for Patent 8,568,979

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Free Forever Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Free Forever Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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