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Generated: August 24, 2019

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Patent: 8,563,521

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Summary for Patent: 8,563,521
Title:Biological active proteins having increased in vivo and/or in vitro stability
Abstract: Increased in vivo and/or in vitro stability is imparted to a biologically active protein by fusing to an amino acid sequence consisting of at least about 100 amino acid residues, which are Alanine, Serine and Proline, which form a random coil conformation. Specific examples are described. Also described are related nucleic acids, vectors and cells encoding such amino acids; compositions of biologically active proteins fused to a random coil domain, and methods of making and using the compounds and compositions of the invention.
Inventor(s): Skerra; Arne (Freising, DE), Theobald; Ina (Landshut, DE), Schlapschy; Martin (Freising, DE)
Assignee: Technische Universitat Munchen (Munich, DE)
Application Number:12/665,565
Patent Claims:see list of patent claims

Details for Patent 8,563,521

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Biovitrum Ab KINERET anakinra VIAL; SUBCUTANEOUS 103950 003 2001-11-14 ➤ Sign Up Technische Universitat Munchen (Munich, DE) 2027-06-21 RX search
Biovitrum Ab KINERET anakinra VIAL; SUBCUTANEOUS 103950 002 2001-11-14 ➤ Sign Up Technische Universitat Munchen (Munich, DE) 2027-06-21 RX search
Biovitrum Ab KINERET anakinra VIAL; SUBCUTANEOUS 103950 001 2001-11-14 ➤ Sign Up Technische Universitat Munchen (Munich, DE) 2027-06-21 RX search
Ekr Therap RETAVASE reteplase VIAL 103786 001 1998-05-06 ➤ Sign Up Technische Universitat Munchen (Munich, DE) 2027-06-21 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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