Compositions and methods for treatment and prevention of insulin resistance
Disclosed herein are methods of delaying the onset or treating diabetes that comprises administering a uric acid lowering agent. The inventors have made the remarkable discovery that elevated uric acid levels are not a corollary to insulin resistance, but rather a primary mediator of insulin resistance. Specifically exemplified are methods that involve administering to a patient susceptible to development of diabetes a composition comprising a uric acid lowering agent in a regimen that maintains serum uric acid levels below at least 5.2 to 5.5 mg/dl.
Johnson; Richard J. (Gainesville, FL), Nakagawa; Takahiko (Gainesville, FL)
University of Florida Research Foundation, Inc. (Gainesville, FL)
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