Perfusion circuit and use therein in targeted delivery of macromolecules
A perfusion circuit and a use thereof for delivering a substance to a subject\'s heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit through a subject\'s heart during a surgical procedure in which the substance is prevented from being delivered to the subject\'s other organs.
Bridges; Charles R. (Charlotte, NC), Stedman; Hansell H. (Norristown, PA), Yarnall; Charles (Lafayette Hill, PA)
The Trustees of the University of Pennsylvania (Philadelphia, PA)
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