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Last Updated: September 29, 2023

Patent: 8,541,203

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Summary for Patent: 8,541,203
Title:Activatable binding polypeptides and methods of identification and use thereof
Abstract: Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an \"activatable\" conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
Inventor(s): Daugherty; Patrick Sean (Santa Barbara, CA), Stagliano; Nancy (Santa Barbara, CA), Thomas; Jerry (Goleta, CA), West; James W. (Santa Barbara, CA), Sagert; Jason (Santa Barbara, CA)
Assignee: The Regents of the University of California (Oakland, CA) CytomX Therapeutics, Inc. (South San Francisco, CA)
Application Number:13/411,416
Patent Claims:see list of patent claims

Details for Patent 8,541,203

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. AVASTIN bevacizumab Injection 125085 02/26/2004 ⤷  Try a Trial 2027-08-22
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 06/30/2006 ⤷  Try a Trial 2027-08-22
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 08/10/2012 ⤷  Try a Trial 2027-08-22
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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