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Last Updated: September 29, 2023

Patent: 8,541,203

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Summary for Patent: 8,541,203

Title:	Activatable binding polypeptides and methods of identification and use thereof
Abstract:	Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an \"activatable\" conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
Inventor(s):	Daugherty; Patrick Sean (Santa Barbara, CA), Stagliano; Nancy (Santa Barbara, CA), Thomas; Jerry (Goleta, CA), West; James W. (Santa Barbara, CA), Sagert; Jason (Santa Barbara, CA)
Assignee:	The Regents of the University of California (Oakland, CA) CytomX Therapeutics, Inc. (South San Francisco, CA)
Application Number:	13/411,416
Patent Claims:	see list of patent claims

Details for Patent 8,541,203

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	AVASTIN	bevacizumab	Injection	125085	02/26/2004	⤷ Try a Trial	2027-08-22
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	06/30/2006	⤷ Try a Trial	2027-08-22
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	08/10/2012	⤷ Try a Trial	2027-08-22
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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