Patent: 8,465,739

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Summary for Patent: 8,465,739

Title:	Stable aqueous pharmaceutical formulations of daclizumab antibodies
Abstract:	This invention is directed to a stable liquid pharmaceutical formulation comprising a high concentration, e.g. 50 mg/ml or more, of antibody in about 20-60 mM succinate buffer or 30-70 mM histidine buffer, having pH from about pH 5.5 to about pH 6.5, about 0.01-0.1% polysorbate, and a tonicity modifier that contributes to the isotonicity of the formulation. This liquid formulation is stable at refrigerated temperature (2-8.degree. C.) for at least 1 year, and preferably 2 years. This liquid formulation is suitable for subcutaneous injection. The preferred antibodies include Daclizumab, a humanized anti-IL-2 receptor monoclonal antibody; HAIL-12, a humanized anti-IL-12 monoclonal antibody; HuEP5C7, a humanized anti-L selectin monoclonal antibody; and Flintozumab, a humanized anti-gamma interferon monoclonal antibody.
Inventor(s):	Kaisheva; Elizabet A. (Belmont, CA), Gupta; Supriya (Sunnyvale, CA), Duvur; Shanti G. (Fremont, CA), Subramanian; Malathy (Fremont, CA)
Assignee:	Abbvie Biotherapeutics Inc. (Redwood City, CA)
Application Number:	13/226,372
Patent Claims:	see list of patent claims

Details for Patent 8,465,739

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Hoffmann-la Roche Inc.	ZENAPAX	daclizumab	Injection	103749	12/10/1997	See Plans and Pricing	2021-11-08
Biogen Inc.	ZINBRYTA	daclizumab	Injection	761029	05/27/2016	See Plans and Pricing	2021-11-08
Biogen Inc.	ZINBRYTA	daclizumab	Injection	761029	05/26/2017	See Plans and Pricing	2021-11-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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