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Last Updated: December 5, 2020

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Patent: 8,445,219

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Summary for Patent: 8,445,219
Title:Method of determination of receptor binding saturation effected by monoclonal antibodies
Abstract: The invention relates to the determination of the degree of membrane receptor binding by specific monoclonal antibodies. This method is notably beneficial for monoclonal antibodies that are used in targeted therapies in order to define a target effective dose (TED). Especially the invention relates to the determination of the saturation degree of receptor binding effected by an anti-EGFR antibody of interest.
Inventor(s): Reiffen; Karl-August (Muehltal, DE), Rosen; Oliver (Boston, MA)
Assignee: Merck Patent GmbH (Darmstadt, DE)
Application Number:13/055,567
Patent Claims:see list of patent claims

Details for Patent 8,445,219

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial Merck Patent GmbH (Darmstadt, DE) 2028-07-25 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Johnson and Johnson

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