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Last Updated: September 22, 2020

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Patent: 8,445,190

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Summary for Patent: 8,445,190
Title:Method of inhibiting biomaterial-induced procoagulant activity using complement inhibitors
Abstract: Methods for reducing or eliminating biomaterial-induced procoagulant activity in blood subjected to extracorporeal treatment that exposes the blood to the biomaterial are disclosed. The methods involve treatment of the blood, or the extracorporeal biomaterial, or both, with a complement inhibitor to inhibit C5a/C5aR-mediated tissue factor formation in the blood.
Inventor(s): Lambris; John D. (Philadelphia, PA), Ritis; Konstantinos (Alexandroupolis, GR)
Assignee: The Trustees of the University of Pennsylvania (Philadelphia, PA)
Application Number:13/121,396
Patent Claims:see list of patent claims

Details for Patent 8,445,190

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Alexion Pharm SOLIRIS eculizumab INJECTABLE; IV (INFUSION) 125166 001 2007-03-16   Start Trial The Trustees of the University of Pennsylvania (Philadelphia, PA) 2039-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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