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Last Updated: December 2, 2021

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Patent: 8,440,799

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Summary for Patent: 8,440,799
Title:Methods of purifying anti A .beta. antibodies
Abstract: The present application provides methods of purifying A.beta. binding proteins having a Fc region, for example, anti-A.beta. antibodies or antibody fusions, by adsorbing the A.beta. binding protein to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt buffer to remove impurities and subsequent recovery of the adsorbed A.beta. binding protein. The present application also features methods of eluting the purified A.beta. binding protein as well as the incorporation of the methods within a purification train. Kits comprising components for carrying out the methods and instructions for use are also provided.
Inventor(s): Godavarti; Ranganathan (Burlington, MA), Iskra; Timothy (Derry, NH)
Assignee: Janssen Alzheimer Immunotherapy (Dublin, IE) Wyeth LLC (Madison, NJ)
Application Number:12/903,053
Patent Claims:see list of patent claims

Details for Patent 8,440,799

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Free Forever Trial 2025-06-17
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Free Forever Trial 2025-06-17
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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