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Generated: September 16, 2019

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Patent: 8,420,684

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Summary for Patent: 8,420,684
Title:Inhibitors of glutaminyl cyclase
Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, ##STR00001## or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein R.sup.1 represents heteroaryl; -carbocyclyl-heteroaryl; -alkenylheteroaryl or -alkylheteroaryl; R.sup.2 represents alkyl which may optionally be substituted by hydroxy; carbocyclyl, which may optionally be substituted by one or more groups selected from alkyl and hydroxy; aryl; -aryl-heteroaryl; -heteroaryl-aryl; -aryl-heterocyclyl; H; heteroaryl; or heterocyclyl, which may optionally be substituted by one or more groups selected from alkyl oxo and hydroxy; R.sup.3 represents alkyl which may optionally be substituted by one of more groups selected from alkoxy, amine, hydroxy and --C(O)Oalkyl; carbocyclyl, which may optionally be substituted by one or more groups selected from alkyl haloalkyl, alkoxy, amine, hydroxy and --C(O)Oalkyl; -alkyl-aryl; -alkyl(aryl).sub.2; -alkyl-heteroaryl; -alkyl(heteroaryl).sub.2; -alkyl(heteroaryl)(aryl); -aryl-O-aryl; aryl; heterocyclyl, -alkyl-C(O)-heterocyclyl, -alkyl-heterocyclyl, -alkyl-C(O)--NR.sup.5-heterocyclyl or -alkyl(heterocyclyl).sub.2 in any of which groups heterocyclyl may be optionally substituted by one or more groups selected from alkyl hydroxy and oxo; -heteroaryl; or -hydroxyalkylaryl; R.sup.4 represents H or C.sub.1-3 alkyl; R.sup.5 represents H or C.sub.1-3 alkyl; and X represents O or S.
Inventor(s): Thormann; Michael (Martinsried, DE), Altmstetter; Michael (Martinsried, DE), Treml; Andreas (Martinsried, DE), Heiser; Ulrich (Halle/Saale, DE), Buchholz; Mirko (Halle/Saale, DE), Niestroj; Andre J. (Sennewitz, DE)
Assignee: Probiodrug AG (Halle-Salle, DE)
Application Number:11/937,146
Patent Claims:see list of patent claims

Details for Patent 8,420,684

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07   Try a Free Trial Probiodrug AG (Halle-Salle, DE) 2036-04-30 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 002 2001-05-07   Try a Free Trial Probiodrug AG (Halle-Salle, DE) 2036-04-30 RX Orphan search
Genzyme LEMTRADA alemtuzumab INJECTABLE;INJECTION 103948 003 2001-05-07   Try a Free Trial Probiodrug AG (Halle-Salle, DE) 2036-04-30 RX Orphan search
Biogen Idec TYSABRI natalizumab VIAL; SINGLE-USE 125104 001 2004-11-23   Try a Free Trial Probiodrug AG (Halle-Salle, DE) 2036-04-30 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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