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Last Updated: September 23, 2020

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Patent: 8,420,089

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Summary for Patent: 8,420,089
Title:Antagonists of IL-6 to raise albumin and/or lower CRP
Abstract: The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of life of a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level or a reduced serum albumin level prior to treatment. In another preferred embodiment, the patient\'s Glasgow Prognostic Score will be increased and survivability will preferably be improved.
Inventor(s): Smith; Jeffrey T. L. (Redmond, WA)
Assignee: AlderBio Holdings LLC (Las Vegas, NV)
Application Number:12/624,965
Patent Claims:see list of patent claims

Details for Patent 8,420,089

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Novartis ARZERRA ofatumumab INJECTABLE; INJECTION 125326 001 2009-10-26   Start Trial AlderBio Holdings LLC (Las Vegas, NV) 2028-11-25 RX search
Novartis KESIMPTA ofatumumab SOLUTION;SUBCUTANEOUS 125326 002 2009-10-26   Start Trial AlderBio Holdings LLC (Las Vegas, NV) 2028-11-25 RX search
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08   Start Trial AlderBio Holdings LLC (Las Vegas, NV) 2028-11-25 RX search
Genentech Inc OCREVUS ocrelizumab INJECTABLE;INJECTION 761053 001 2017-03-28   Start Trial AlderBio Holdings LLC (Las Vegas, NV) 2028-11-25 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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