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Last Updated: September 18, 2020

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Patent: 8,389,492

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Summary for Patent: 8,389,492
Title:Lyophilized DNA formulations for enhanced expression of plasmid DNA
Abstract: The present invention provides for a method of treating or preventing ischemic or liver disease in a subject by administering a composition reconstituted from a lyophilized hepatocyte growth factor (HGF) DNA formulation, where the DNA formulation comprises an HGF plasmid DNA, salt and a carbohydrate. The invention further provides for a method of making such a lyophilized DNA formulation that preserves or enhances gene expression both in vitro and in vivo, thus maintaining or stimulating the biological activity of the expressed protein. The invention also provides for the DNA formulation, or the lyophilized DNA formulation according to the methods disclosed.
Inventor(s): Kim; Jong-Mook (Seoul, KR), Kim; Sujeong (Seoul, KR), Hahn; Woong (Goyang-si, KR), Yoo; WonSun (Seoul, KR)
Assignee: ViroMed Co., Ltd. (KR)
Application Number:13/045,460
Patent Claims:see list of patent claims

Details for Patent 8,389,492

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial ViroMed Co., Ltd. (KR) 2028-04-09 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial ViroMed Co., Ltd. (KR) 2028-04-09 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial ViroMed Co., Ltd. (KR) 2028-04-09 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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